Memantine Alleviates Toxicity Induced by Dichlorvos in Rats

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Memantine alleviates toxicity induced by dichlorvos in rats.

The changes of N-methyl-D-aspartate (NMDA) receptor and protective efficacy of memantine (MEM) in rats poisoned with dichlorvos were studied. Dichlorvos evoked down-regulation of the affinity and density of [(3)H]MK-801 binding to NMDA receptor in the brain of rats receiving dichlorvos (15 and 25 mg/kg bw, i.p.). The binding capacity of NMDA receptor and acetylcholinesterase activity were deter...

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ژورنال

عنوان ژورنال: Journal of Occupational Health

سال: 2005

ISSN: 1341-9145,1348-9585

DOI: 10.1539/joh.47.96